Turmeric is one of the most valued medicinal plants in the world. Native to the Indian subcontinent, today it is used globally as a nutritional supplement,spice,natural food coloring and as an ingredient innatural cosmetics. Its popularity stems from ancient Ayurvedic medicine, which described the many health benefits of turmeric more than 2,500 years ago. In modern times, it is modern science that its active compounds, especially curcumin, can be scientifically confirmed and effective izkoristimo.Eden of the most recognized and researched extracts is Sabinsa Curcumin C3 Complex® – a patented form obtained from the dried rhizomes of the plant Curcuma longa. This extract is standardized to at least 95% curcuminoids, ensuring high efficacy and bioavailability.

 is the most scientifically researched extract of turmeric (Curcuma longa), boasting more than 150 scientific publications and 79 clinical studies confirming its effectiveness and safety. It is a standardized extract with 95% curcuminoids, which for more than 30 years has enjoyed the trust of users throughout svetu.Nadzorovana cultivation and top quality Sabinsa grows its turmeric on contract farms, where Good Agricultural Practices (GAP) are strictly followed. The entire production process takes place in facilities controlled by US FDA and is certified to the highest standards:

[[t712]USP-GMP (good manufacturing practice),
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• FSSC 22000:2005 (safe food).

Each batch of Curcumin C3 Complex® is rigorously tested against more than 100 types of pesticides and verified by radiocarbon analysis, which confirms 100% natural source of ingredients. Verified purity and safety This unique turmeric extract boasts recognized international certificates:

• TRU-ID - confirms the authenticity of plant ingredients,
  
• Non-GMO Verified - no genetically modified organisms,
  
• GRAS status - officially recognized as safe by the US FDA.
  
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Awarded and appreciated worldwide Curcumin C3 Complex® has received many prestigious awards, including among them:

• Scientific Achievement Award (NBJ, 2007),
  
• Product Merit Award (NBJ, 2008),
  
• Marketing Excellence Award (Functional Ingredients, 2012),
  
• NutraIngredients-USA Award (2016).

Curcumin and related curcuminoids, natural active compounds in the turmeric plant (Curcuma longa), have many scientifically supported health benefits. 

Below we summarize the main results from various clinical studies on Curcumin C3 Complex®:

1. Support in COVID-19 (mild to moderate disease course) (1)

[[t184]Study: An open-label, unstructured clinical study in hospitalized patients with COVID-19.

• Findings: Ingestion of nano-curcumin accelerated the disappearance of symptoms (fever, cough, muscle pain), improved oxygen saturation and reduced hospital stay. None of the patients in the curcumin group experienced disease worsening, which was the case in 40% of the control group.
  
• Conclusion: Curcumin C3 can support faster recovery in patients with COVID-19 without adverse effects.
  
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2. Reducing inflammation and oxidative stress in severe head injury (2)

[[t872]Study: A randomized, double-blind, placebo-controlled trial.

• Findings: Curcuminoids significantly reduced inflammatory biomarkers (IL-6, TNF-α, CRP) and improved clinical outcomes and nutritional status of patients.
  
• Conclusion: Short-term supplementation of Curcumin can significantly reduce inflammation and support recovery in critically ill injured patients heads.
  

3. Improvement of functional dyspepsia symptoms (3)

• Study: Randomized, triple-blind, placebo-controlled trial.
  
[[t1502]Findings: The combination of curcumin and famotidine reduced the symptoms of dyspepsia and reduced the prevalence of Helicobacter pylori infection.
[[t1668]Conclusion: Curcumin C3 can effectively improve digestive problems and reduce chronic inflammation gastric mucosa.


4. Effects on adipokines in critically ill patients with TBI (4)

[[t1894]Study: Randomized, double-blind, placebo controlled.

• Findings: Curcuminoid supplementation decreased leptin levels, which are associated with inflammation, while having no effect on adiponectin.
  
• Conclusion: Curcumin C3 contributes to the regulation of inflammation and metabolic markers in critically ill patients.
  
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5. Reducing inflammation in nonalcoholic fatty liver disease (NAFLD) (5)

• Studies: Randomized, double-blind, placebo-controlled trial.
  
[[t2472]Findings: Curcuminoids reduced body weight, improved liver status after ultrasound, and decreased inflammatory cytokines such as TNF-α and MCP-1.

• Conclusion: Curcumin C3 supports liver health by reducing inflammation and fatty changes.
  
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6. Antioxidant effects in patients with renal failure and type 2 diabetes (6)

• Study: Randomized controlled trial.
  
• Findings: The supplement of 2000 mg of Curcumin C3 significantly increased the antioxidant capacity of the blood and contributed to the successful maturation of arterio-venous fistula in patients on dialysis.
  
[[t3167]Conclusion: Curcumin C3 plays an important role in protecting the vascular system and improving the health of patients with kidney diseases.

1. Shafiee A. et al. Curcumin for the treatment of COVID-19 patients: A meta-analysis of randomized controlled trials. Phytother Res. 2023;37(3):1167–1175. PMID:36640146
2. Abdolahi M. et al. The effects of curcuminoids on inflammatory markers in traumatic brain injury: randomized double-blind trial. Phytother Res. 2020. PMID:32291880
3. Bundhun PK. et al. Curcumin and famotidine in functional dyspepsia: randomized triple-blind placebo-controlled trial. Clin Transl Gastroenterol. 2021. PMID:34115936
4. Asghari Jafarabadi M. et al. Curcuminoids supplementation and adipokines in traumatic brain injury patients: randomized controlled trial. J Diet Suppl. 2020. PMID:32814477
5. Panahi Y. et al. Curcuminoids in non-alcoholic fatty liver disease: randomized double-blind placebo-controlled trial. Phytother Res. 2017;31(12):1907–1914. PMID:28921839
6. Khajehdehi P. et al. Curcumin improves oxidative stress and vascular function in hemodialysis patients with type 2 diabetes. Clin Nutr. 2011;30(4):475–480. PMID:21493055
7. Clinical Evidence - Curcumin C3 Complex (selection of clinical RCTs and trials). curcuminoids.com/clinical-evidence (active link)
   

📚Pharmacology & Clinical Trials
[[t1318]8. Curcumin/Piperine - IND study approved: IND# 61,872Food & Drug Administration Office of Drug Evaluation I, Division of Oncology Drug Products

9. The effects of Curcuminoids on aberrant crypt foci in the human colon: IND# 51,685UMDNJ - Robert Wood Johnson Medical School, New Jersey Cancer Institute

10. Pilot study of curcuminoids with or without BioPerine® in patients with multiple myeloma: IND# 67,963MD Anderson Cancer Center, University of Texas

11. Prevention and intervention of Alzheimer's disease with curcuminoidsUniversity of California, Los Angeles

12. Curcuminoids in patients with Lichen planus: IND#65,700/S-000University of California

13. Phase IIa prevention study of C3 Complex®curcuminoids in women at increased risk for breast cancerMD Anderson Cancer Center, University of Texas

14. The clinical and laboratory effects of topical curcuminoids in patients with normal skin and with dysplastic and benign neviNational Cancer Institute

15. Phase II prevention study with C3 Complex® in patients with colorectal cancer stage I-IIILincoln Medical and Mental Health Center, Bronx, NY

16. Phase I trial of C3 Complex® and precooperative patients with locally advanced esophageal or gastroesophageal carcinomaMD Anderson Cancer Center, University of Texas

17. Metabolic studies and chemopreventive studies, University of Leicester, UK Liacini, A. et al. Matrix Biol. 2002 Apr;21(3):251-62

3- https://curcuminoids.com/clinical-evidence